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One fundamental necessity in the entire process of a well-performed study is the experimental design. A well-designed study can help researchers understand and have confidence in their results and analyses, and additionally the agreement or disagreement with the stated hypothesis. This well-designed study also gives confidence to the scientific community of the objectivity and purity of findings. Often, however, the specific questions and objectives of a researcher’s study are not fully developed when designing the experiment. This misstep often leads to difficulty in properly analyzing studies, and in some cases, decreases the usefulness of the data that has already been collected. The purpose of this talk is to explain why deciding on the overarching question we are trying to answer in our research is the most important first step in conducting research. Once the question has been distilled, we can move on to the best study design to create an unbiased, objective, controlled experiment with adequate replication and without confounding. Some of the important factors to consider when designing an experiment are identifying which factors to control and which to vary, what specifically needs to be measured, the number of replications, the cost of the experiment, quantitative vs. qualitative factors, and how the study will be analyzed. Taking all of these factors into consideration helps to create a strong design with high statistical power and a straight-forward analysis.