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03 Issues & Trends
Cereal Foods World, Vol. 63, No. 4
DOI: https://doi.org/10.1094/CFW-63-4-0152
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FODMAP Reduction in Yeast-Leavened Whole Wheat Bread
Nore Struyf, Joran Verspreet, and Christophe M. Courtin1
Laboratory of Food Chemistry and Biochemistry and Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Leuven, Belgium

1 Laboratory of Food Chemistry and Biochemistry and Leuven Food Science and Nutrition Research Centre (LFoRCe), KU Leuven, Kasteelpark Arenberg 20, B-3001 Leuven, Belgium.


Abstract

Patients suffering from irritable bowel syndrome (IBS) should follow a very strict diet that is low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs), which are small, osmotically active molecules that are poorly absorbed in the small intestine and rapidly fermented by bacteria in the large intestine. To accomplish this they must avoid consumption of most cereal products. Removal of cereal products from the diet has negative health effects, however, because cereal grains are a major source of energy, dietary fiber, vitamins, and minerals in the diet. To enable IBS patients to consume nutritious whole wheat breads without negative health effects, the FODMAP levels in these breads must be reduced. Different strategies can be applied for this purpose, including the use of an alternative yeast species for fermentation (Kluyveromyces marxianus) or the addition of enzymes such as inulinase. When addition of alternative ingredients is not desirable, adaptations to the breadmaking process, such as a prolonged proofing time, may be utilized to reduce FODMAP levels.





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References

  1. Caballero, R., Olguín, P., Cruz-Guerrero, A., Gallardo, F., García-Garibay, M., and Gómez-Ruiz, L. Evaluation of Kluyveromyces marxianus as baker’s yeast. Food Res. Int. 28:37, 1995.
  2. Gibson, P. R., and Shepherd, S. J. Evidence‐based dietary management of functional gastrointestinal symptoms: The FODMAP approach. J. Gastroenterol. Hepatol. 25:252, 2010.
  3. Goldstein, R., Braverman, D., and Stankiewicz, H. Carbohydrate malabsorption and the effect of dietary restriction on symptoms of irritable bowel syndrome and functional bowel complaints. Isr. Med. Assoc. J. 2:583, 2000.
  4. Hagberg, S. A rapid method for determining alpha-amylase activity. Cereal Chem. 37:218, 1960.
  5. Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., and Muir, J. G. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology 146:67, 2014.
  6. Haskå, L., Nyman, M., and Andersson, R. Distribution and characterisation of fructan in wheat milling fractions. J. Cereal Sci. 48:768, 2008.
  7. Hungin, A., Whorwell, P., Tack, J., and Mearin, F. The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 40 000 subjects. Aliment. Pharmacol. Ther. 17:643, 2003.
  8. Huynh, B.-L., Palmer, L., Mather, D. E., Wallwork, H., Graham, R. D., Welch, R. M., and Stangoulis, J. C. R. Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J. Cereal Sci. 48:369, 2008.
  9. Marsh, A., Eslick, E. M., and Eslick, G. D. Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis. Eur. J. Nutr. 55:897, 2016.
  10. Nilsson, U., Öste, R., and Jägerstad, M. Cereal fructans: Hydrolysis by yeast invertase, in vitro and during fermentation. J. Cereal Sci. 6:53, 1987.
  11. Ong, D. K., Mitchell, S. B., Barrett, J. S., Shepherd, S. J., Irving, P. M., Biesiekierski, J. R., Smith, S., Gibson, P. R., and Muir, J. G. Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome. J. Gastroenterol. Hepatol. 25:1366, 2010.
  12. Pedersen, N., Vegh, Z., Burisch, J., Jensen, L., Ankersen, D. V., Felding, M., Andersen, N. N., and Munkholm, P. Ehealth monitoring in irritable bowel syndrome patients treated with low fermentable oligo-, di-, mono-saccharides and polyols diet. World J. Gastroenterol. 20:6680, 2014.
  13. Ravich, W., Bayless, T., and Thomas, M. Fructose: Incomplete intestinal absorption in humans. Plast. Reconstr. Surg. 72:747, 1983.
  14. Rouwenhorst, R. J., Ritmeester, W. S., Scheffers, W. A., and Van Dijken, J. P. Localization of inulinase and invertase in Kluyveromyces species. Appl. Environ. Microbiol. 56:3329, 1990.
  15. Rouwenhorst, R. J., Visser, L. E., Van Der Baan, A. A., Scheffers, W. A., and Van Dijken, J. P. Production, distribution, and kinetic properties of inulinase in continuous cultures of Kluyveromyces marxianus CBS 6556. Appl. Environ. Microbiol. 54:1131, 1988.
  16. Shepherd, S. J., Lomer, M. C., and Gibson, P. R. Short-chain carbohydrates and functional gastrointestinal disorders. Am. J. Gastroenterol. 108:707, 2013.
  17. Staudacher, H., Whelan, K., Irving, P., and Lomer, M. Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome. J. Hum. Nutr. Diet. 24:487, 2011.
  18. Staudacher, H. M., Lomer, M. C., Anderson, J. L., Barrett, J. S., Muir, J. G., Irving, P. M., and Whelan, K. Fermentable carbohydrate restriction reduces luminal bifidobacteria and gastrointestinal symptoms in patients with irritable bowel syndrome. J. Nutr. 142:1510, 2012.
  19. Struyf, N., Laurent, J., Verspreet, J., Verstrepen, K. J., and Courtin, C. M. Substrate-limited Saccharomyces cerevisiae yeast strains allow control of fermentation during bread making. J. Agric. Food Chem. 65:3368, 2017.
  20. Struyf, N., Laurent, J., Verspreet, J., Verstrepen, K. J., and Courtin, C. M. Saccharomyces cerevisiae and Kluyveromyces marxianus cocultures allow reduction of fermentable oligo-, di-, and monosaccharides and polyols levels in whole wheat bread. J. Agric. Food Chem. 65:8704, 2017.
  21. Struyf, N., Vandewiele, H., Herrera-Malaver, B., Verspreet, J., Verstrepen, K. J., and Courtin, C. M. Kluyveromyces marxianus yeast enables the production of low FODMAP whole wheat breads. Food Microbiol. 76:135, 2018.
  22. Truswell, A. S., Seach, J. M., and Thorburn, A. Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose. Am. J. Clin. Nutr. 48:1424, 1988.
  23. Tuck, C. J., Muir, J. G., Barrett, J. S., and Gibson, P. R. Fermentable oligosaccharides, disaccharides, monosaccharides and polyols: Role in irritable bowel syndrome. Expert Rev. Gastroenterol. Hepatol. 8:819, 2014.
  24. Van der Walt, J., and Johannsen, E. Discussion of the genera belonging to the ascosporogenous yeasts. Kluyveromyces van der Walt emend. van der Walt. Page 224 in: The Yeasts: A Taxonomic Study, 3rd ed. N. J. W. Kreger-Van Rij, ed. Elsevier Science Publishers, Amsterdam, 1970.
  25. Varney, J., Barrett, J., Scarlata, K., Catsos, P., Gibson, P. R., and Muir, J. G. FODMAPs: Food composition, defining cutoff values and international application. J. Gastroenterol. Hepatol. 32:53, 2017.
  26. Verspreet, J., Dornez, E., Van den Ende, W., Delcour, J. A., and Courtin, C. M. Cereal grain fructans: Structure, variability and potential health effects. Trends Food Sci. Technol. 43:32, 2015.
  27. Verspreet, J., Hemdane, S., Dornez, E., Cuyvers, S., Delcour, J. A., and Courtin, C. M. Maximizing the concentrations of wheat grain fructans in bread by exploring strategies to prevent their yeast (Saccharomyces cerevisiae)-mediated degradation. J. Agric. Food Chem. 61:1397, 2013.
  28. Ziegler, J. U., Steiner, D., Longin, C. F. H., Würschum, T., Schweiggert, R. M., and Carle, R. Wheat and the irritable bowel syndrome—FODMAP levels of modern and ancient species and their retention during bread making. J. Funct. Foods 25:257, 2016.