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Consumption of whole grains has shown to benefit against diabetes, cardiovascular disease and obesity among other lifestyle diseases; and their nutritional and bioactive components have been underlined to synergistically help prevent and manage them. The 2015 Dietary Guidelines for Americans reinforced the consumption of whole grains given the recurring low dietary patterns among the majority of the U.S. population.  Germination has re-emerged has a promising natural process to enhance the nutritional profile and bioactivity of whole grains. Efficacy data regarding the effect of sprouted grains on blood glucose, lipid profile, inflammation, and oxidative stress among others via <i>in-vitro</i> studies is rising, however substantiating <i>in-vivo</i> and randomized control human studies are lagging behind. A review of the current research on the nutritional efficacy of germinated edible grains will be presented.